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unwelcome side effects such as restlessness, sleepiness, weight gain and some abnormal lab test results such as increased cholesterol levels, the researchers reported.
"The evidence supporting the use of antipsychotics in depression is marginal," said lead researcher Glen Spielmans, an associate professor in the department of psychology at Metropolitan State University in St. Paul, Minn.
The new analysis found these drugs offered only a small benefit in relieving symptoms of depression and little or no benefit in improving patients' quality of life or ability to function.
inactive placebo in patients for whom antidepressants weren't enough to relieve depression.
For some patients, however, these antipsychotics can be helpful, including those with insomnia and those whose depression is coupled with a psychosis, he noted.
"Studies were sometimes designed in a biased manner that may have slanted the results," Spielmans said. "Data were sometimes reported in a way that likely made the drugs appear more effective than they actually were."
Spielmans suggested that some of the trials they looked at may have tried to boost the perception of the effectiveness of the drug and downplay its side effects.
"I prefer using other strategies like adding other antidepressants, or using brain stimulation treatments, and psychotherapy," Bruno said.
For one expert, these drugs also aren't a first choice for patients who don't respond fully to antidepressants.
"Other options may be as effective, or more effective, and carry a lesser side effect burden," Spielmans said. For instance, cognitive behavioral therapy has been shown to be effective for treatment resistant depression, he said. Cognitive behavioral therapy is a treatment that helps patients try to change their thoughts, feelings and behaviors.Bruno, acting chair of psychiatry at Lenox Hill Hospital, in New York City.
"I treat a lot of patients who are on antidepressants and not responding well. Prescribing these drugs is not something I do often because of the costs and because of the side effects," said Bruno, who was not involved with the study.
The drugs did, however, have some Lacoste Grey T Shirt
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"I have mixed results in terms of how effective they are," said Dr. Bryan Lacoste Golf Caps
This process, called a meta analysis, attempts to T Shirt Design Uk Cheap find common threads from different studies that reveal a pattern, which adds information beyond what one study finds.
Some of these drugs are pricey. For example, Abilify can cost more than $200 a month without insurance, according to the Everyday Health website. With insurance the cost varies by plan.
Antipsychotic Meds Not That Helpful for Depression
The report was published in the March issue of the online journal PLoS Medicine.
Antipsychotic treatment of depression has become increasingly widespread but the underlying evidence base puts this practice into question, he said.
To gauge the effectiveness of these drugs, Spielmans' team pooled data from 14 studies that compared antipsychotic medications to an Fred Perry Green
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